(41 reviews)
$115.25 CAD
$2.31 CAD Cashback
Single Bottle (30 Servings)
SKU: C13083
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Primary Benefits of Prime Joint Support Formula by Isotonix®

The only product on the market delivering Glucosamine and Pycnogenol® in one.

  • A factor in maintaining healthy cartilage
  • Helps to maintain healthy cartilage
  • A factor in maintaining joint health
  • Helps to maintain joint health

Primary Benefits of Prime Joint Support Formula by Isotonix®

Support for the Joints

What Makes Prime Joint Support Formula by Isotonix Unique?

What Makes Prime Joint Support Formula by Isotonix Unique?

As the body ages, many people experience joint discomfort. One option is to take a joint supplement to help promote overall bone and joint health. When looking at a joint supplement, there is one main non-controversial ingredient found in most products on the market, glucosamine. The research behind glucosamine is consistent and its benefits effective. Prime Joint Support Formula by Isotonix® contains glucosamine, naturally produced by the body and a key component of cartilage. An aminomonosaccharide (a combination of the amino acid — glutamine and a sugar — glucose), glucosamine is concentrated in joint cartilage and has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates your joints and regenerates cartilage.

Prime Joint Support Formula also contains the powerful antioxidant Pycnogenol®, which science has shown to inhibit the body’s overactive inflammatory processes associated with the normal aging process. The body’s inflammatory response is a natural process. It is an essential component of the body’s defense system and can be triggered from numerous internal and external factors. Pycnogenol® has been shown to help support the body’s defense system by inhibiting overactive inflammatory responses associated with the normal aging process. Furthermore, Prime Joint Support Formula is the only product on the market delivering glucosamine and Pycnogenol® in isotonic form.

*Pycnogenol® is a registered trademark of Horphag Research, Ltd.

Product Classifications

Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

No Detectable GMOs - The finished product contains no detectable genetically-modified organisms

Isotonic-Capable Drinkable Supplements - Easy-to-swallow supplements in liquid form are immediately available to the body for absorption

Quality Standards - GMP Operations and Standardised Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Potency, Purity and Identity

Isotonix Delivery System

Isotonix- the World's Most Advanced Nutraceuticals
Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state. Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Isotonix Delivery System

Key Ingredients

Glucosamine (HCl)
Glucosamine is a molecule that is naturally synthesized in the body from glucose and the amino acid glutamine. Glucosamine is an important constituent of glycosaminoglycans in cartilage matrix and synovial fluid. As our bodies age, we are less able to produce glucosamine, resulting in cartilage that is less flexible and weak. Although the mechanism is currently unclear, studies have shown that glucosamine supplementation can support normal, healthy cartilage cell production to help maintain overall joint health.

Pine Bark Extract (Pycnogenol®)

Pycnogenol® is a water-soluble flavonoid complex with powerful benefits. Pycnogenol®, similar to the proanthocyanins found in grape seeds, is extracted from the bark of the French maritime pine tree. Numerous studies have examined the anti-inflammatory properties of Pycnogenol®. The body’s inflammatory response is a natural process. It is an essential component of the body’s defense system, and can be triggered from numerous internal and external factors. Pycnogenol® has been shown help maintain the body’s natural defenses by inhibiting over active inflammatory responses associated with the normal aging process. Research has shown that Pycnogenol® may inhibit the activation of NF-kappa B and AP-1, both of which are proinflammatory mediators. Pycnogenol® supplementation can also promote normal COX-2 and 5-LOX gene expression and support healthy leukotriene biosynthesis. In addition, studies have shown the ability of Pycnogenol® to cross-link collagen fibers and strengthen connective tissue proteins.


  1. What is the recommended dosage?
    Pour 3 level, white bottle capfuls of powder into a cup. Add 6 fl. oz of (the line on the overcap indicates 2 fl. oz.) of water and stir. Maximum absorption occurs when taken with a meal. This product is isotonic only if the specified amounts of powder and water are used.

  2. What other products should I take with Prime Joint Support Formula by Isotonix to support my joint health?
    Heart Health Essential Omega III is a great pair with Prime Joint Support Formula, as omega III fatty acids have been shown to support healthy joint lubrication.

  3. How often should I take Prime Joint Support Formula by Isotonix?
    This product is most effective when taken daily.

  4. How much Pycnogenol is in Prime Joint Support Formula by Isotonix?
    There are 25 milligrams of Pycnogenol in each daily serving.

  5. Who should not use this product?
    Women who are pregnant or breastfeeding should not use this product. If you are currently taking warfarin (Coumadin) or any other antiplatelet/anticoagulant drugs, anti-hypertensive drugs, any prescription drug or have an ongoing medical condition, you should consult your healthcare provider before using this product. If you have a known allergy to shellfish, do not use this product.


  • Barringer T et al. Potential Benefits on Impairment of Endothelial Function after a High-fat Meal of 4 weeks of Flavonoid Supplementation. Evidence-based Complementary and Alternative Medicine: eCAM. doi:10.1093/ecam/nen048: 1-6, 2008.
  • Belcaro, G., et al. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol. Redox Report. 13(6): 271-276, 2008.
  • Blewis, M., et al. A model of synovial fluid lubricant composition in normal and injured joints. European Cells and Materials. 13: 26-39, 2007.
  • Braham, R., et al. The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine. 37(1): 45-49, 2003.
  • Canali, R., et al. The anti-inflammatory pharmacology of Pycnogenol in humans involves COX-2 and 5-LOX mRNA expression in leukocytes. International Immunopharmacology. 9(10): 1145-1149, 2009.
  • Cesarone MR et al. Improvement in circulation and in cardiovascular risk factors with a proprietary isotonic bioflavonoid formula OPC-3. Angiology. 59(4):408-14, 2008.
  • Cesarone MR et al. Accelerated antioxidant bioavailability of OPC-3 bioflavonoids administered as isotonic solution. Phytotherapy Research. 23(6):775-7, 2009.
  • Chou, M., et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Experimental Biology and Medicine. 230(4): 255-262, 2005.
  • Cisár, P., et al. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytotherapy Research. 22: 1087-1092, 2008.
  • Farid, R., et al. Pycnogenol supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis. Nutrition Research. 27: 692-697, 2007.
  • Gaby, A. Natural treatments for osteoarthritis. Alternative Medicine Review. 4(5): 330-341, 1999.
  • Gouze, J., et al. Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Research and Therapy. 8(6): R173
  • Grimm, T., et al. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). Journal of Inflammation. 3: 1-15, 2006.
  • Hua, J., et al. Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils. Journal of Leukocyte Biology. 71(4): 632-640, 2002.
  • James, C. and Uhl, T. A review of articular cartilage pathology and the use of glucosamine sulfate. Journal of Athletic Training. 36(4): 413-419, 2001.
  • Laurent, T., et al. Functions of hyaluronan. Annals of the Rheumatic Disease. 54(5): 429-432, 1995.
  • Kelly, G. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Alternative Medicine Review. 3(1): 27-39, 1998.
  • Nakatani, S., et al. Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5. Biological and Pharmaceutical Bulletin. 30(3): 433-438, 2007.
  • Natural Medicines Comprehensive Database- www.naturaldatabase.com Pycnogenol
  • NHPD database: Glucosamine HCl - 2009-June
  • Poustie, M., et al. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. 311(2): 610-616, 2004.
  • Reginster, J., et al. Current concepts in the therapeutic management of osteoarthritis with glucosamine. Bulletin (Hospital for Joint Disease). 63(1-2): 31-36, 2005.
  • Reginster, J., et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet. 357(9252): 251-256, 2001.
  • Richy, F., et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of Internal Medicine. 163(13): 1514-1522, 2003.
  • Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. International Journal of Clinical Pharmacology and Therapeutics. 40(4):158-168, 2002.
  • Schäfer, A., et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol). Biomedicine and Pharmacotherapy. 60: 5-9, 2006.

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Displaying reviews  1 - 5 of 41


by RickyL

Good product

Foot joint is better than ago after used😋

Response from Customer Service:

Dear Valued Customer,

Thank you for your positive feedback on our Prime Joint Support Formula by Isotonix! We're delighted to hear that you've experienced improvements in your joint health. Your satisfaction is our top priority.

We appreciate your support and look forward to serving your wellness needs in the future!

The Product Information Team


by Anonymous

Awesome product!

This product really works! All in one formula. Love it

Response from Customer Service:

Dear Valued Customer,

Thank you for taking the time to leave your thoughts on Prime™ Joint Support Formula by Isotonix®. We are happy to hear you are pleased with the product.

Thank you again!
Market Singapore Product Team



Shop Consultant

Very east to take. Highly recommend.

Response from Customer Service:

Dear Valued Customer,

Thank you for taking the time to share your thoughts on the Prime™ Joint Support Formula by Isotonix®! We are so happy to hear you are pleased with the product!

Thank you again!
The Product Information Team


by BobbijoD


This product is amazing it has helped my husband so much with his joints he works in construction

Response from Customer Service:

Dear Valued Customer,

Thank you for taking the time to share your thoughts on the Prime Joint Support Formula by Isotonix! We are happy to hear you are pleased with the product.

Thank you again!
The Product Information Team



Shop Consultant
Prime Joint is keeping me in my PRIME.

After a 14 year career as a National level Gymnast and 3 seasons as Captain of the Toronto Raptors Trampoline Stunt Team, my joints were shot. By my mid 30's I couldn't even climb the stairs in my house without pulling myself up using the railing to help relieve the pain in my joints. A personal trainer friend of mine worked with a dietitian who recommended I take Isotonix OPC-3, Calcium and Glucosatrin. To my happy surprise I was virtually pain free after 3 months and was able to run up the stairs pain free. Then Isotonix came out with PRIME Joint Support Formula, well that just put me over the top! I've been pain free ever since. I'm still weight training hard in the gym 5 days per week for 1.5 hours per day.

Rodney D.